Why is it prescribed?
Bosentan is used for the treatment of pulmonary arterial hypertension (PAH).
See other drugs used in the treatment of •
If you are a man taking Bosentan it is possible that this medicine may lower your sperm count. It cannot be excluded that this may affect your ability to father a child. Talk to your doctor if you have any questions or concerns about this.
If these side effects become bothersome, contact your doctor:
- nausea and vomiting
- abdominal pain
- skin rash
- inflammation of the throat and nasal passages
- swelling of the legs and ankles, or other signs of fluid retention
- low blood pressure
- irregular heartbeat
If you notice yellowing of the skin or eyes (jaundice) or other symptoms such as nausea, vomiting, fever, abdominal pain or unusual tiredness, see your doctor immediately because this may be related to abnormal liver function.
Bosentan belongs to a class of medications known as "endothelin receptor antagonists". It is used to treat pulmonary arterial hypertension or PAH and works by relaxing the blood vessels between the heart and lungs thereby reducing abnormally high blood pressure.
Do not use Bosentan if you:
- have liver problems;
- are pregnant or planning to become pregnant
- are a woman of childbearing age and not using adequate contraception. Bosentan may make hormonal contraception (e.g., oral, injection, implant or skin patches) ineffective, this method on its own is not reliable. Therefore, if you use hormonal contraceptives you must also use a barrier method (e.g., female condom, diaphragm, contraceptive sponge or your partner must also use a condom). Monthly pregnancy tests are recommended while you are taking Bosentan and you are of childbearing age
Drug Interactions: Tell your doctor and your pharmacist if you are taking:
- cyclosporine A or any other drugs used to prevent rejection of transplanted organs;
- fluconazole or ketoconazole
- vasodilators (drugs used to treat high blood pressure)
- simvastatin and other statins
- hormonal contraceptives.
Use in pregnancy: Bosentan has the potential to cause birth defects and should not be used if pregnant or planning to get pregnant.
Use in breastfeeding: It is not known whether bosentan is transferred to breastmilk. Use is not recommended in breastfeeding women.