Medications

PMS-Sodium Cromoglycate nebulizer solution   

This product is manufactured by Pharmascience Inc. using the ingredient sodium cromoglycate (cromolyn sodium).

This product is taken via nebulizer.

Why is it prescribed?

Sodium cromoglycate is used on a continual basis for the prevention of the symptoms of asthma. It is also indicated for the prevention of bronchospasm associated with known causative factors (e.g. exercise, cold air, allergies, pollutants, etc.). Sodium cromoglycate, as a nasal spray, is used for prevention of the symptoms of allergic rhinitis (hay fever).


PMS-Sodium Cromoglycate nebules are meant for inhalation only via a nebulizer.
Your doctor, pharmacist or health care provider will instruct you on the proper use and care of the nebulizer. Make sure you understand exactly how to use it before proceeding. The ampules should be stored at room temperature (15 to 30 degrees centigrade). Protect from light.  Discard any unused sterules in opened foil packages after 3 months.  

Instructions For Use:
1. The contents of the sterules are to be inhaled from a nebulizer. Do not open the foil pack until the sterules are required.
2. Prepare the nebulizer for filling according to the manufacturer’s instructions.
3. To open the foil pack lift the foil at the black arrow and peel. Do not peel the lid of completely. Remove the sterules.
4. To detach a sterule, push one sterule downwards and away while holding the remaining sterules securely. Return the remaining sterules to the foil tray, cover the tray with the foil lid and place the tray back in the carton.
5. Holding the top of the sterule securely, twist the body to open.
6. Place the open end of the sterule well into the nebulizer cup and squeeze slowly. Ensure the contents are emptied into the nebulizer cup.
7. Assemble the nebulizer and use as directed.
8. Breathe calmly and evenly as much as possible until no more mist is formed in the nebulizer chamber. At this point, treatment is finished.
9. After use discard any solution remaining in the nebulizer cup. Clean the nebulizer according to the manufacturer’s instructions.

 


Alternatives

Other products that have the same ingredient as PMS-Sodium Cromoglycate nebulizer solution are •Rhinaris CS® nasal mist •

See other products used in the treatment of •allergic rhinitis •allergies •asthma •exercise-induced bronchospasm •hay fever •rhinitis •runny nose •seasonal allergies •seasonal rhinitis •year-round allergies •

The usual dose for an adult is one ampule via inhalation four times a day (every 6 hours). In severe cases, inhalation may be increased to a maximum of 8 ampules per day. Once stabilized, the dose may be reduced, usually to one ampule every 8 to 12 hours.


Sodium cromoglycate is a drug that blocks the release of inflammatory chemical messengers from specific cells in the body called mast cells. Upon inhaling particles (e.g. pollen, smoke, etc.) that irritate the lining of the breathing passages, a person's mast cells respond by releasing chemicals to protect the body. The chemicals cause an inflammatory process resulting in bronchoconstriction and swelling of the tissues lining the breathing passages causing an obstructed airflow. Sodium cromoglycate blocks the release of these mast cell chemicals and prevents the inflammatory process. Sodium cromoglycate is not a bronchodilator.


Along with its needed effects, sodium cromoglycate may cause some unwanted or undesirable effects. Generally, sodium cromoglycate is well tolerated and many people will not experience unwanted effects. The severity and duration of these effects are dependant on many factors including duration of therapy, dose, route of administration and individual response. Possible unwanted effects include:

  • throat irritation or dryness (oral inhalation only)
  • bad taste in mouth
  • cough
  • sneezing (nasal spray only)
  • nasal irritation (nasal spray only)

Uncommon:

  • wheeze
  • nausea
  • headache


Rare:


  • bronchospasm (oral inhalation only)
  • rash or hives
  • joint swelling and pain


Many of these unwanted effects, especially the most common ones, may disappear with continued use of the medication. Check with your doctor or pharmacist if you are concerned or they become bothersome.


People using sodium cromoglycate inhalation for treatment of asthma must understand that this medication is not a bronchodilator and should not be used as a rescue medication in acute asthmatic episodes. Sodium cromoglycate will only work properly if it is taken on a regular basis. Sporadic use, or only using your medication when you are experiencing symptoms, will lead to poor symptom control.
Optimal effectiveness can be hampered if the delivery device is not used properly. Even if you have used a puffer or nasal spray before, you should have your technique reassessed by your pharmacist and read the patient instructions that are provided with the product.
Don't expect sodium cromoglycate to start working immediately when you initiate therapy. Improvement will generally occur within the first few weeks of starting the medication. An improvement may be noticed as either a decrease in your symptoms or less dependance on other medication that you are using to relieve symptoms.
Never stop using sodium cromoglycate abruptly, especially if your symptoms have been partially or completely controlled by the medication. Sudden withdrawal may result in a rapid return of symptoms. If discontinuing sodium cromoglycate, it is advised to gradually reduce your dose over the course of one week before stopping completely. If you must stop suddenly, consult you doctor or pharmacist.

Drug Interactions: Sodium cromoglycate does not appear to have any significant interactions with other medications. However, it is wise to tell your doctor and pharmacist about any prescription or over-the-counter medications you are taking to ensure safety.

Use is not recommended in the following situations:

  • allergy to sodium cromoglycate or any ingredient in the product
  • certain types of pneumonia

Use in pregnancy: Considered compatible with pregnancy.
Use while breastfeeding: Although human data is limited, use is considered compatible with breastfeeding.

 


Page Last Updated: 05/10/2016