Medications

PMS-Fluconazole tablets   

This product is manufactured by Pharmascience Inc. using the ingredient fluconazole.

This product is taken orally.


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orally


Why is it prescribed?

Fluconazole is used to treat many fungal infections. This material will be limited to the treatment of candidiasis (yeast) infections of the mouth, throat and esophagus (food pipe).


In general, PMS-Fluconazole tablets are taken once daily. If you miss a dose, take it as soon as possible. If more than several hours have passed or it is almost time for your next dose, do not double dose (unless you have been told to do so). Contact your pharmacist if you are not sure what to do.
It should be taken at the same time each day.  Store this medication at room temperature.
PMS-Fluconazole tablets can be taken with food.
You may be instructed to start your first day of therapy with twice the normal daily dose. This is done so the body can start fighting the infection more quickly.


Alternatives

Other products that have the same ingredient as PMS-Fluconazole tablets are •Act-Fluconazole tablets •Apo-Fluconazole tablets •Diflucan® suspension •Mylan-Fluconazole tablets •PRO-Fluconazole tablets •Teva-Fluconazole tablets •

See other products used in the treatment of •candidiasis •thrush •yeast infection of the mouth and throat •

For candidal infections of the mouth and throat: Adults usually take 100 mg once daily for 2 weeks. In children the usual dose is 3 mg per kilogram of body weight once daily for 2 weeks.
For candidal infections of the esophagus: Adults usually take 100 to 200 mg once daily for at least 2 weeks after the symptoms have disappeared or a minimum of 3 weeks. The dose for children is from 3 mg to 6 mg per kilogram of body weight for at least 2 weeks after the symptoms have disappeared or a minimum of 3 weeks.


Fluconazole is an antifungal agent. It works by interfering with the formation of the fungal cell membrane.


Along with its needed effects, fluonazole may cause some unwanted or undesirable effects. Generally, fluconazole is well tolerated and many people will not experience unwanted effects. The frequency and severity of these effects is dependant on many factors including dose, duration of therapy and individual susceptibility. In general, fluconazole is well tolerated. Possible unwanted effects include:

  • nausea
  • vomiting
  • diarrhea
  • headache
  • skin rash

Fluconazole should be taken exactly as prescribed. If you experience a rash, yellowing of skin or eyes, nausea, weakness, difficulty breathing or facial swelling contact your doctor immediately.
Drug Interactions: It is important to tell your doctor and pharmacist about any prescription or over-the-counter medications you are taking to help avoid any serious drug interactions. The dose of one or both medications may need to be altered or a new drug may be prescribed. In some cases, one of the drugs may have to be discontinued. The following drugs and drug classes have been known to interact with fluconazole.

  • acid blockers (e.g. cimetidine)
  • rifampin
  • warfarin (e.g. Coumadin®)
  • cyclosporine (e.g. Neoral®)
  • theophylline (e.g. Theo-Dur®)
  • phenytoin (e.g. Dilantin®)
  • hydrochlorothiazide
  • diabetes medication (e.g. glyburide)
  • oral contraceptives (e.g.Triphasil®)
  • zidovudine

Use is not recommended in the following situations:

  • allergy to fluconazole or any component of the preparation

Caution is recommended in the following situations:

  • kidney disease
  • liver disease
  • allergy to other azole antifungals (e.g. ketoconazole)


Use in pregnancy: If you suspect that you may be pregnant contact your doctor.
Use while breastfeeding: It is likely that fluconazole does pass into the breast-milk. Consult your doctor or pharmacist before use.


Page Last Updated: 05/10/2016