Medications

Apo-Cefprozil tablets   

This product is manufactured by Apotex Inc. using the ingredient cefprozil.

This product is taken orally.


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orally


Why is it prescribed?

Cefprozil is used to treat infections caused by various bacteria. This material will be limited to the treatment of respiratory tract infections (e.g. pharyngitis, tonsilitis, sinusitis)and middle ear infections.


Use exactly as prescribed. Apo-Cefprozil tablets can be taken with food to decrease possible stomach upset. Take Apo-Cefprozil tablets at even intervals around the clock as prescribed (e.g. every 12 hours translates to twice a day) until finished. Failure to take the complete course can result in incomplete elimination of the bacteria which can lead to a relapse of the infection. The prescribed course generally lasts a few days longer than symptoms of the infection (e.g. fever). Duration of therapy is usually 10 to 15 days. If you miss a dose, take it as soon as possible. If it is almost time for your next dose, do not take 2 doses at once (unless you have been instructed to do so). Contact your pharmacist if you are not sure what to do. Apo-Cefprozil tablets may produce an allergic reaction which can range in severity from a mild rash or itching to a life-threatening reaction. Contact your doctor or pharmacist if you experience rash, itching, fever, difficulty breathing, chest tightness or anything else that alarms you. If diarrhea occurs (severe or persistent), contact your doctor or pharmacist.


Alternatives

Other products that have the same ingredient as Apo-Cefprozil tablets are •Auro-cefprozil tablet •RAN-Cefprozil suspension •RAN-Cefprozil tablets •Sandoz Cefprozil tablets •

See other products used in the treatment of •middle ear infections •pharyngitis •respiratory tract infections •sinusitis •sore throat •tonsilitis •upper respiratory tract infections •sleep apnea •

The usual adult dose is 500 mg every 24 hours or 250mg to 500mg every 12 hours. Dosing for children is dependent on their weight, the infection being treated and the severity of the infection. The dose for treating respiratory tract infections in children can range from 7.5 mg to 15 mg per kg of body weight every 12 hours.


Cefprozil is an antibiotic medication that kills various bacteria. It works by inhibiting the synthesis of one of the building blocks needed for the bacteria to make it's cell wall. This results in a cell wall that is defective and more likely to rupture. The effectiveness of cefprozil depends on factors such as dose, concentration in the blood as well as other body fluids and tissue, and the susceptibility of the bacteria. Cefprozil does not kill all types of bacteria, but only those that have a sensitivity to this antibiotic. Infections caused by bacteria that are not sensitive to cefprozil will not show improvement after taking this medication.


Along with its needed effects, cefprozil may cause some unwanted or undesirable effects. Generally, cefprozil is well tolerated and many people will not experience unwanted effects. The frequency and severity of these effects is dependant on many factors including dose, duration of therapy and individual susceptibility. Possible unwanted effects include:

  • diarrhea
  • nausea
  • vomiting

Uncommon:

  • stomach ache
  • itching in genital and vaginal area
  • allergic reaction (hives, itching, rash, difficulty breathing)

Rare:

  • headache
  • nervousness
  • hyperactivity
  • dizziness

Taking the antibiotic repeatedly or for prolonged periods may result in bacterial or fungal overgrowth which can lead to a second infection. When this occurs, the cefprozil may need to be stopped and another antibiotic prescribed to treat the new infection.
Diarrhea often develops while taking cefprozil. This is sometimes caused by an overgrowth of bacteria in the gut that are not killed by the antibiotic. In severe cases, this may be life threatening and would require treatment with other antibiotics. In mild cases, symptoms disappear shortly after the drug is discontinued.
There is evidence to show that people who are allergic to penicillin may also be allergic to cefprozil and vice versa. Be sure to inform your doctor and pharmacist of any antibiotic allergy or suspected allergy that you may have had in the past.

Drug Interactions: It is important to tell your doctor and pharmacist of any prescription or over-the-counter medications you are taking. Interactions have been known to occur between cefprozil and probenecid (e.g. Benemid®). Use is not recommended in the following situations:

  • allergy to cephalosporins (e.g. cephalexin)

False positive direct Coombs' tests (test used in detecting a type of blood disorder) may be caused by cefprozil.Cefprozil may cause false urine test results for glucose.

Caution is recommended in the following situations:

  • kidney disease
  • allergy to penicillin
  • stomach or intestinal disease (e.g. colitis)
  • prolonged, repeated therapy

Use in pregnancy: Can be used in pregnancy if necessary, however, other medications is this family are preferred.  Consult your doctor or pharmacist if you suspect you are pregnant.
Use while breastfeeding: Cefprozil does appear in breast-milk, but in small amounts.  Generally considered safe for use in breastfeeding. Consult your doctor or pharmacist before use.


Page Last Updated: 05/10/2016